two new seco polycyclic polyprenylated acylphloroglucinol

two new seco polycyclic polyprenylated acylphloroglucinol
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Two new seco-polycyclic polyprenylated acylphloroglucinol ...

Hypsampsone A (1) and hyperhexanone F (2), two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii. Hypsampsone A (1) features the first spirocyclic system fused with 5/6/5/5 tetracyclic skeleton. Hyperhexanone F (2) represents the second novel 1,2-seco-b …Cited by: 2Publish Year: 2021Author: Zi-Zhen Zhang, Yan-Rong Zeng, Ya-Nan Li, Zhan-Xing Hu, Lie-Jun Huang, Wei Gu, Xiao-Jiang Hao, Chun-M...sp.info Two new seco-polycyclic polyprenylated acylphloroglucinol ...Abstract. Hypsampsone A ( 1) and hyperhexanone F ( 2 ), two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii. Hypsampsone A ( 1) features the first spirocyclic system fused with 5/6/5/5 tetracyclic skeleton. Hyperhexanone F ( 2) represents the second novel 1,2-seco-bicyclo [3.3.1]-PPAP skeleton.Cited by: 2Publish Year: 2021Author: Zi-Zhen Zhang, Yan-Rong Zeng, Ya-Nan Li, Zhan-Xing Hu, Lie-Jun Huang, Wei Gu, Xiao-Jiang Hao, Chun-M...Is Accessible For Free: Falsesp.info Two new seco-polycyclic polyprenylated acylphloroglucinol ...Two novel seco-polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbenzones A (1) and B (2), were isolated from the roots of Hypericum beanii, together with one known biosynthetic congener...sp.info Two new seco-polycyclic polyprenylated acylphloroglucinol ...Nov 12, 2020 · Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii. Coronavirus: Find the latest articles and preprints Sign in or create an account. https://orcid.org. Europe PMC. Menu. About. About Europe PMC; Preprints in Europe PMC; Funders; Joining Europe PMC; Governance ...Cited by: 2Publish Year: 2021Author: Zi-Zhen Zhang, Yan-Rong Zeng, Ya-Nan Li, Zhan-Xing Hu, Lie-Jun Huang, Wei Gu, Xiao-Jiang Hao, Chun-M...

Hypericum sampsonii Supplementary Information Two …

1 Supplementary Information Two new seco-Polycyclic Polyprenylated Acylphloroglucinol from Hypericum sampsonii Zi-Zhen Zhang,a,b,c Yan-Rong Zeng,a,c Ya-Nan Li,a,c Zhan-Xing Hu,a,c Lie-Jun Huang, a,b,c Wei Gu, a,b,c Xiao-Jiang Hao,a,b,c,d , Chun-Mao Yuan a,b,c, a State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, …sp.info Hyperbenzones A and B, two 1,2-seco and rearranged ...Nov 10, 2021 · Two novel seco -polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbenzones A ( 1) and B ( 2 ), were isolated from the roots of Hypericum beanii, together with one known biosynthetic congener 3. Compound 1 incorporates a 6/5/5 ring system with an unprecedented spiro [bicyclo [3.3.0]octane-3,1ʹ-cyclohexane]-2,2ʹ-dione motif.sp.info Frontiers | New Polyprenylated Acylphloroglucinol ...Hypericum wilsonii N. Robson, which also belongs to the Hypericum genus and has been found to contain 1,2-seco-homoadamantane–type polycyclic polyprenylated acylphloroglucinols (PPAPs) (Xie et al., 2020a), is a kind of shrub, growing on hillsides, under forests, or grasslands, at an altitude of 1,000–1750 m. It is mainly distributed in Hubei and Sichuan provinces as well as …Author: Ji Hao, Tongxi Zhou, Yuanren Ma, Jingtong Deng, Haitao Cheng, Qiang Wang, Qinxiong Lin, Xinzhou Yang...Publish Year: 2021sp.info Hypersubones A and B, New Polycyclic Acylphloroglucinols ...Feb 20, 2015 · Hypersubones A and B (1, 2), two adamantane type polycyclic polyprenylated acylphloroglucinols possessing an unprecedented seco-adamantane architecture and a tetracyclo-[6.3.1.1 3,10.0 4,8]-tridecane core combined with a peroxide ring, respectively, were isolated from Hypericum subsessile together with three analogues (3–5). Their structures were …

New Acylphloroglucinol Derivatives with Diverse ...

Abstract. Hyphenrones A–F ( 1 – 6 ), six polycyclic polyprenylated acylphloroglucinol derivatives with four architectures including three unprecedented cores as exemplified by 1, 3, and 4, were isolated from Hypericum henryi. Compounds 3 and 4 possess two unique 5/8/5 and 6/6/5/8/5 fused ring systems, respectively.sp.info Chemical constituents from the flowers of Hypericum ...In this study, sixteen chemical monomers, including three undescribed oxidative degradation polycyclic polyprenylated acylphloroglucinols (PPAPs, hypemoins C–E), two undescribed PPAPs (hypemoins A and B), and 11 known compounds, were identified from the flowers of H. monogynum. Their structures were characterized by HRESIMS, NMR techniques ...Author: Ya-Nan Li, Yan-Rong Zeng, Jue Yang, Wenwen He, Junlei Chen, Lulu Deng, Ping Yi, Lie-Jun Huang, Wei G...Publish Year: 2022sp.info Polycyclic Polyprenylated Acylphloroglucinols | Request PDFTwo novel seco-polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbenzones A (1) and B (2), were isolated from the roots of Hypericum beanii, together with one known biosynthetic congener...Estimated Reading Time: 7 minssp.info Research advances on CYP450-catalysed pharmaceutical ...Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii. Zizhen Zhang, Yanrong Zeng, +5 authors Chunmao Yuan; Chemistry, Medicine; Organic & biomolecular chemistry; 2020; Save. Alert. Research Feed. References. SHOWING 1-10 OF 92 REFERENCES. SORT BY. Cytochrome P450-enzymes involved in the biosynthesis of mono- …

Polycyclic polyprenylated acylphloroglucinol with an ...

Abstract: Spirohypatone A (1), a spirocyclic PPAP (polycyclic polyprenylated acylphloroglucinol) bearing an unprecedented hexahydro-1'H-spiro [cyclohexane-1, 2'-pentalene]-2, 4, 6-trione core and a new homologue (spirohypatone B, 2) were isolated from Hypericum patulum together with two known biosynthetic precursors. Compound 1 represents …sp.info A new cytotoxic polycyclic polyprenylated ...A new polycyclic polyprenylated acylphloroglucinol ( 1 ), nujiangefolin D, together with five known analogues ( 2–6 ), were isolated from the fruits of Garcinia nujiangensis. Compound 1 was screened by the LC-MS and LC-PDA. The structure of 1 was elucidated on the basis of extensive spectroscopic techniques including 1 D and 2 D NMR and MS analyses.Cited by: 4Publish Year: 2020Author: Zhongyan Tang, Lihua Lu, Xiaoyong Zhou, Jie Shen, Weiping Song, Yuedong Tang, Zhengxiang Xiasp.info Hyperacmosins K–M, three new polycyclic polyprenylated ...Hyperacmosins K–M (1–3), three new polycyclic polyprenylated acylphloroglucinol (PPAPs) derivatives, were isolated from the air-dried aerial parts of Hypericum asmosepalum. Compounds 1 and 2 both possessed a rare 5,5-spiroketal subunit with the loss of C-2′ carbonyl in the phloroglucinal ring, while compound 3 featured an unusual 1,2-seco ...sp.info Research Progress of Polycyclic Polyprenylated ...Hypsampsone A and hyperhexanone F, two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii and showed moderate multidrug resistance reversal activity to adriamycin resistant cancer cell lines.

Two New Xanthones from Hypericum sampsonii and …

Phytochemical investigation of the CH 2 Cl 2 extract of the aerial part of Hypericum sampsonii yielded two new prenylated xanthones, hypericumxanthone A and B, together with three known xanthones. Their structures were elucidated by analysis of physical and spectral (UV, IR, mass and NMR) data and comparison of spectroscopic data with those reported previously.sp.info Frontiers | Natural Products Research in China From 2015 ...This review covers the literature published by chemists from China during the 2015–2016 on natural products (NPs), with 1,985 citations referring to 6,944 new compounds isolated from marine or terrestrial microorganisms, plants, and animals. The emphasis is on 730 new compounds with a novel skeleton or/and significant bioactivity, together with their source …sp.info Polycyclic Polyprenylated Acylphloroglucinol Derivatives ...The characteristic components in Hypericum are mainly a series of polycyclic polyprenylated acylphloroglucinols (PPAPs), flavonoids, and xanthones. Among them, the PPAPs have received much attention due to their novel structures and diverse pharmacological activities and have become hot spots in organic chemistry and medicinal chemistry.sp.info Hyperisampsins H–M, Cytotoxic Polycyclic Polyprenylated ...Oct 06, 2015 · Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H–M (1–6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7 ...

Polycyclic Polyprenylated Acylphloroglucinol Congeners ...

Their acylphloroglucinol core structure is produced by a characteristic polyketide-type biosynthesis involving the condensation of one acyl-CoA and three malonyl-CoA units.1,3 Prenylation of this core moiety affords monocyclic polyprenylated acylphloroglucinols (MPAPs), which may be further cyclized to PPAP-type metabolites with diverse carbon ...sp.info Hyperisampsins H–M, Cytotoxic Polycyclic Polyprenylated ...Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H–M (1–6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7–11).The structures of 1–6 were established by extensive spectroscopic analyses, including HRESIMS and NMR. In addition, the absolute configurations of these new …sp.info The Phytochemistry and Pharmacology of Hypericum ...Dec 12, 2020 · Yang XW, Deng X, Liu X, Wu CY, Li XN, Wu B, Luo HR, Li Y, Xu HX, Zhao QS, Xu G (2012) Hypercohin A, a new polycyclic polyprenylated acylphloroglucinol possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens. Chem Commun 48:5998 Google Scholarsp.info Total Syntheses of Polycyclic Polyprenylated ...Polycyclic polyprenylated acylphloroglucinols (PPAPs) are structurally complex natural products with promising biological activities. These compounds have interesting anticancer and anti-HIV properties as well as other biological activities making them highly attractive synthetic targets. We report a stereodivergent, asymmetric total synthesis of (-)-clusianone in six steps from …

Author: "Kong, Ling-Yi" - PubAg Search Results

Two new type B polycyclic polyprenylated acylphloroglucinols (PPAPs) (1 and 2) and a known biogenetic precursor hyperbeanol Q (3) were isolated from the root extract of Hypericum beanii, a medicinal plant widespread in southwest China.sp.info Publications----Kunming Institute of Botany,CASXing-Wei Yang, Xu Deng, Xia Liu, Chun-Yan Wu, Xiao-Nian Li, Bin Wu, Huai-Rong Luo, Yan Li, Hong-Xi Xu, Qin-Shi Zhao, Gang Xu*, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chem. Commun., 2012, 48, 5998–6000. 22.sp.info Journal: Journal of natural products / Publication Year ...The asymmetric total synthesis of five decarbonyl polycyclic polyprenylated acylphloroglucinols norsampsnes A (3) and B (4), garcinielliptones O (5) and N (6), and hyperscabrin A (7) is described. The synthesis to construct the core substituted cyclohexanone ring of these natural products was achieved by a key Dieckmann condensation.sp.info "PROGRESS TOWARDS THE SYNTHESIS OF TYPE B …Plants of the family Guttiferae produce polycyclic polyprenylated acylphloroglucinols (PPAPs), which have interesting biological activities including anticancer and antibacterial properties. The main structural features of PPAPs comprise of bicyclo[3.3.1]nonane-2,4,9-triketone with one acyl group together with prenyl, geranyl, or other C10H17 groups. 7-epi-Clusianone, a type B …

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